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  • Home
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  • Members
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Publications

  1. Kho S-H, Yee JY, Puang SJ, Han L, Chiang LLC, Rapisarda A, Goh WWB, Lee J, and Sng J (2022) DNA methylation levels of RELN promoter region in Ultra-high Risk, First Episode and Chronic Schizophrenia cohorts of Schizophrenia. Schizophrenia (in press)
  2. Yee JY, Chow SQ, Lim K, Goh W, Sng J, Lee TS, Lee J. (2022) Haptoglobin in ultra-high risk of psychosis - Findings from the longitudinal youth at risk study (LYRIKS). Brain Behav Immun Health. 12;23:100481. Link
  3. Schnyder S and Sng J (2021) Dance And Jive Well Into Your Senior Life. AIC, November issue. Link
  4. Puang, S.J., Elanggovan, B., Ching, T. & Sng J.C.G. (2020). MEF2C and HDAC5 regulate Egr1 and Arc genes to increase dendritic spine density and complexity in early enriched environment. Neuronal Signal, 4 (3): NS20190147. Link
  5. Ho, N. F., Tng, J.,  Wang, M., Chen, G., Subbaraju, V., Shukor, S., Ng, D., Tan, B. L.,  Puang, S. J., Kho, S. H., Siew, R., Sin, G. L., Eu, P. W., Zhou, J.,  Sng, J., Sim, K., & Medalia, A. (2020). Plasticity of DNA  methylation, functional brain connectivity and efficiency in cognitive  remediation for schizophrenia. Journal of psychiatric research, S0022-3956(19)31081-7. Link
  6. Shun Qiang Lo, Judy C. G. Sng & George J. Augustine (2017) Defining a critical period for inhibitory circuits within the somatosensory cortex. Scientific Reports 7, Article number: 7271. Link
  7. Begum MR and Judy C.G. Sng (2017) Molecular mechanisms of experience-dependent maturation in cortical GABAergic inhibition. J Neurochem 42:649-661. Link
  8. Wilson Wen Bin Goh, Judy Chia-Ghee Sng, Jie Yin Yee, Yuen Mei See, Tih-Shih Lee, Limsoon Wong, Jimmy Lee. (2017) Can peripheral blood-derived gene expression characterize individuals at ultra-high risk for psychosis? Computational Psychiatry, 1: 168-183. Link
  9. Ohba K, Sinha RA, Singh BK, Iannucci LF, Zhou J, Kovalik J-P, Liao X-H, Refetoff S, Sng JCG, Leow MK-S, Yen PM (2017) Changes in Hepatic TRβ Protein Expression, Lipogenic Gene Expression, and Long-Chain Acylcarnitine Levels During Chronic Hyperthyroidism and Triiodothyronine Withdrawal in a Mouse Model.Thyroid 27(6):852-860. Link
  10. Lee PK, Goh WW and Judy Sng (2017) Network-based characterization of the synaptic proteome reveals that removal of epigenetic regulator Prmt8 restricts proteins associated with synaptic maturation. J Neurochem, 140(4):613-628. Link
  11. Oikawa H, Sng JC (2016) Valproic acid as a microRNA modulator to promote neurite outgrowth. Neural Regen Res 11(10):1564-1565.Link
  12. Dawn Koh and Judy C. G. Sng (2016) HDAC1 negatively regulates Bdnf and Pvalb required for parvalbumin interneuron maturation in an experience-dependent manner. J Neurochem, 139(3):369-380. Link
  13. Kenji Ohba, Melvin Khee-Shing Leow, Brijesh Kumar Singh, Rohit Anthony Sinha, Ronny Lesmana, Xiao-Hui Liao, Sujoy Ghosh, Samuel Refetoff, Judy Chia Ghee Sng and Paul Michael Yen (2016) Desensitization and incomplete recovery of hepatic target genes after chronic thyroid hormone treatment and withdrawal in male adult mice. Endocrinology, 157(4), 1660–1672. Link , Highlighted in News and Views
  14. Andreas Lennartsson, Erik Arner, Michela Fagiolini, Alka Saxena, Robin Andersson, Hazuki Takahashi, Yukihiko Noro, Judy Sng, Albin Sandelin, , Takao K. Hensch and Piero Carninci (2015) Remodeling of retrotransposon elements during epigenetic induction of adult visual cortical plasticity by HDAC inhibitors. Epigenetics and Chromatin, 8:55. Link
  15. Hirotaka Oikawa, Wilson W.B. Goh, Vania K.J. Lim, Limsoon Wong, Judy C.G. Sng (2015) Valproic acid mediates miR-124 to down-regulate a novel protein target, GNAI1. Neurochemistry International, 91: 62-71. Link
  16. SQ Lo, Dawn X. P. Koh, Judy C. G. Sng and George Augustine (2015) All-optical mapping of barrel cortex circuits based on simultaneous voltage-sensitive dye imaging and channelrhodopsin-mediated photostimulation. Neurophotonics, 2(2), 021013. Link
  17. Piero Ricchiuto, Judy C.G. Sng, Wilson Wen Bin Goh. (2015) Analyzing extremely small sized ratio datasets. IJBRA, 11(3), 268-280. Link
  18. Wilson Goh, Wong Limsoon and Judy C. G. Sng. (2014) Contemporary Network Proteomics and Its Requirements. Biology, 3, 22-38 (Invited review). Link
  19. Wilson Goh, Marek Sergot, Judy C. G. Sng* and Wong Limsoon*. (2013) Comparative network-based recovery analysis and proteomic profiling of neurological changes in valproic acid-treated mice. Journal of Proteome Research, 12 (5), pp 2116–2127. (*co-corresponding authors) Link
  20. Dawn Koh and Judy C.G. Sng. (2012) Research Highlights: Highlights from the latest articles on DNA methylation. Epigenomics. 4, 601-603 (Invited article). Link
  21. Wilson Goh, Hirotaka Oikawa, Judy C. G. Sng, Marek Sergot and Wong Limsoon. (2011) The role of miRNAs in complex and control. Bioinformatics, 28, 453-456. Link
  22. Jan Paul Buschdrof, Patrick K.M. Lee, Vania K. J. Lim, Lauren Kappeler and Judy Sng. (2010) Epigenetics goes translational. Epigenomics. 2, 509-512 (Invited article). Link
  23. Judy Sng and Michael J. Meaney. (2009) Environmental regulation of the neural epigenome. Epigenomics. 1, 131-151. Link
  24. Hideo Taniura, Judy C. G. Sng, Yukio Yoneda (2007) Histone Modifications in the brain. Neurochem Int, 51:85-91. Link
  25. Hideo Taniura, Judy C. G. Sng, Yukio Yoneda (2006) Histone Modifications in status epilepticus induced by kainate. Histol Histopathol. 21, 785-795. Link
  26. Judy C. G. Sng, Hideo Taniura, Yukio Yoneda (2006) Histone Modifications in Kainate-induced Status Epilepticus. Eur. J. Neurosci. 23, 1269-1282. Link
  27. Takao Hirai, Hideo Taniura, Yasuaki Goto, Masato Ogura, Judy C.G. Sng and Yukio Yoneda (2006) Stimulation of ubiquitin-proteasome pathway through the expression of amidohydrolase for N-terminal asparagine (Ntan1) in cultured rat hippocampal neurons exposed to static magnetism. J. Neurochem. 96, 1519-1530. Link
  28. Judy C. G. Sng, Hideo Taniura, Yukio Yoneda (2005) Inhibition of histone deacetylation by trichostatin A intensifies the transcriptions of neuronal c-fos and c-jun genes after kainate stimulation. Neuroscience Letters 386(3):150-155. Link
  29. Judy C. G. Sng, Hideo Taniura, Yukio Yoneda (2004) A tale of early response genes. Biol. Pharm. Bull. 27, 606-612. (Cover illustration) Link
  30. Shirhan M, Moochhala SM, Siew Yang KL, Sng J, Ng KC, Mok P, Lu J. (2004) Preservation of neurological functions by nitric oxide synthase inhibitors in conscious rats following delayed hemorrhagic shock. Life Sci. 76(6):661-70. Link


PDF downloads

MEF2C and HDAC5 regulate Egr1 and Arc genes to increase dendritic spine density and complexity in early enriched environment (pdf)Download
Plasticity of DNA methylation, functional brain connectivity and efficiency in cognitive remediation for schizophrenia (pdf)Download
Defining a critical period for inhibitory circuits within the somatosensory cortex (pdf)Download
Contemporary Network Proteomics and Its Requirements (pdf)Download
Network‐based characterization of the synaptic proteome reveals that removal of epigenetic regulator Prmt8 restricts proteins associated with synaptic maturation (pdf)Download
Remodeling of retrotransposon elements during epigenetic induction of adult visual cortical plasticity by HDAC inhibitors (pdf)Download
All-optical mapping of barrel cortex circuits based on simultaneous voltage-sensitive dye imaging and channelrhodopsin-mediated photostimulation (pdf)Download
Valproic acid mediates miR-124 to down-regulate a novel protein target, GNAI1 (pdf)Download
Histone modifications in kainate-induced status epilepticus (pdf)Download
Inhibition of histone deacetylation by trichostatin A intensifies the transcriptions of neuronal c-fos and c-jun genes after kainate stimulation (pdf)Download
A tale of early response genes (pdf)Download

Theses produced in our lab

PhD Theses

  1. Lee Kia Ming Patrick (2016) Characterisation of structural plasticity of the visual cortex in PRMT8 null mice. Link
  2. Koh Xin Ping Dawn (2015) HDAC1 negatively regulates bdnf transcription and parvalbumin maturation in an experience-dependent model of the mouse barrel cortex. Link
  3. Lo Shun Qiang (2014) Imaging experience-dependent plasticity in the mouse barrel cortex. Link
  4. Wilson Goh Wen Bin (2013) Computational Proteomics Using Network-Based Strategies. Link


Honours Theses

  1. Glenn Gunadi (2016) Correlation between BDNF serum level, DNA methylation, and the symptoms severity in the first episode psychosis patients. 
  2. Lee Tim Wei (2016) Study of Hyperphagia through Necdin knock-out reveals its influence on hunger-satiety circuitry.
  3. Lim Yan Yin (2016) Unravelling the role of Necdin in appetite control via network-based proteomics.
  4. Michaelpone Sufian (2016) Investigating the Role of Necdin in Appetite Control via Network-based Transcriptomics.
  5. M Ridzwana Begum (2016) Controlling epigenetic regulation of experience-dependent plasticity with optogenetics.
  6. Puang Shu Juan (2016) Risperidone decreases reelin DNA methylation in patients diagnosed with first episode psychosis.
  7. Regina Hong (2016) An evaluation of students' attitudes and preferences with respect to webcasted lectures: Does digital tagging improve their usefulness?
  8. Zoe Ang (2016) An evaluation of students' attitudes and preferences with respect to video graphic materials: Does digital tagging improve their usefulness?
  9. Lee Xin Hui (2017) Necdin knockout perturbs parvalbumin inhibitory interneuron’s population and morphology.
  10. Loke Jiawei (2017) Overexpression of Hdac1 and its effect on critical period plasticity.
  11. M Prakash (2017) Removal of perineuronal nets in visual cortices of adult murine Prmt8+/- restores visual acuity.
  12. Chen Yitong (2019) Effect of Early Life Experiences on the Epigenetic Changes of RELN Gene and Development of Schizophrenia.
  13. Lee Tzeng Suan (2019) Evaluation of the DNA methylation of brain-derived neurotrophic factor (bdnf) gene promoter I as a biomarker in psychiatric disorders. 
  14. Nur Syazana Binte Roslan (2019) DNA hypomethylation in the enhancer and promoter regions of reln gene correlate the severity of patients with major depressive disorder and schizophrenia. 
  15. Rachel Siew Wan En (2019) Less severe depressive symptoms in females of transgenic mouse model of Huntington’s disease linked to higher Bdnf expression and lower DNA methylation levels.
  16. Thiang Hui Ning (2019) Anti-psychotic medication decreases reelin DNA methylation in patients diagnosed with first episode psychosis.
  17. Lim Eu Jin (2020) A direct comparison across brain regions and neural populations in mouse model of Huntington's disease reveals Bdnf expression and DNA methylation differences.
  18. Oh Sher Li (2020) Reduced expression and pCREB binding at Bdnf promoters I and IV in YAC128 mouse model of Huntington’s disease.
  19. Shivaanishaa Raventhiran (2020) Understanding the role of HDAC2 in regulating Bdnf expression in early-and-late-stages of Huntington's Disease Mouse Model.
  20. Ma Ze Jing Jordan (2021) Epigenetic contribution to dysregulation of myelin-related genes in YAC128 Huntington's disease mouse model. 
  21. Shamieraah Jamal (2021) Contribution of GLT1 and NMDARs to Excitotoxicity at the Onset of Huntington's Disease in a YAC128 Model.
  22. Wee Xiao Wen (2022) Involvement of Excitotoxicity in Neurodegeneration using the Huntington’s disease Mouse Model.

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